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KMID : 0858420110130020066
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Korean Journal of Stroke
2011 Volume.13 No. 2 p.66 ~ p.73
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Association between Single Nucleotide Polymorphisms of α2A-, α2B-, and α2C- Adrenergic
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Kim Mi-Hwa
An Se-A
Lee Han-bin
Choo Seung-Wook
Kim Nam-Keun
Kim Won-Chan
Kim Ok-Joon
Oh Seung-Hun
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Abstract
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Background: An α2-adrenergic receptor (α2-AR, ADRA2) mediates induction of hypotension and inhibition of lipolysis and insulin secretion. We evaluated whether single nucleotide polymorphisms (SNPs) of α2A (ADRA2A), α2B (ADRA2B), and α2C (ADRA2C)adrenergic receptors are associated with cerebral white matter lesion (cWML).
Methods: Total 336 study subjects who had no stroke were enrolled in this study. The Indices of cWML include total WML (TWML), periventricular WML(PVWML), and subcortical WML (SCWML) on brain fl uid-attenuated inversion recovery (FLAIR) image. Common genetic variants of ADRA2A (1780G>A), ADRA2B (Ins/Del301-303), and ADRA2C (Ins/Del322-325) were examined.
Results: Among 336 study subjects, cWML was found in 66 patients (20%). In multivariate analysis, there were no signifi cant effects of all tested ADRA2 polymorphisms on TWML. Signifi cant association of ADRA2A 1780 AA genotype was found in PVWML(OR: 3.368, 95% CIs: 1.280-8.865, adjusted p-value after false discovery rate (FDR) correction=0.014) but not SCWML.
Conclusion: Although SNPs of three ADRA2 subtypes failed to reach a signifi cance in overall risk for cWML, the ADRA2A 1780G>A polymorphism may be associated with development of PVWML.
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KEYWORD
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Alpha2-adrenergic receptor, Polymorphism, Cerebral white matter lesion
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